Liporase mainly contains hyaluronidase, an enzyme that easily dissolves hyaluronic acid (HA) by speeding up the body’s absorption rate. Daehan New Pharm Co. developed it to correct unsatisfactory results from dermal filler injections, such as overfilling, uneven distribution, incorrect placement, or accidental injection into the vein.

It is important to emphasize that Liporase specifically acts on synthetic hyaluronic acid, rapidly reversing the effects of the dermal filler without causing harm to the body’s natural hyaluronic acid. Liporase can enhance the efficacy of fat-dissolving injections. Liporase Hyaluronidase is verified and approved by the KFDA as a dissolving agent. Additionally, it possesses several indications that can substantially impact attaining the desired results, including enhancing the absorption and dispersion of other administered medications, enhancing the delivery of subcutaneous fluids, and promoting the absorption of radiopaque agents.

BENEFITS

1. Main choice of corrective solution for unsatisfactory dermal filler injection results.
2. Enhances the effectiveness of fat-dissolving injections.
3. Increases the dissolution rate of hyaluronic acid and its absorption in the body.
4. It can also reduce body fat due to its very high enzymatic activity.
5. Comes in a cost-effective package for the convenience of the patient and doctor.

COMPOSITION

Liporase contains 1500IU of hyaluronidase and 13.3mg of lactose hydrate as a preservative.

APPLICATION

Liporase can be administered in locations where filler injections have shown poor outcomes, particularly in the facial area and lips. Liporase may be administered via injection in any of the following conditions:

1. Overfilling of HA-based dermal fillers.
2. When dermal fillers are unevenly distributed.
3. When the filler is accidentally injected into the intra-arterial vein.
4. In cellulite-forming areas.
5. Excess body fat.

HOW TO USE

Liporase is a Class III Medical Device certified and created in a manufacturing facility that follows current Good Manufacturing Practices (cGMP). Clinical trials have provided evidence of its safety and effectiveness. Nevertheless, it is essential to exercise caution before administering Liporase. 

Before administering Liporase, it is necessary to do a patch test on patients to ascertain the presence of any allergic response. First, administer Liporase via subcutaneous injection and observe for any allergic reaction for 20 minutes. It is essential to be aware that a small amount of redness and swelling at the injection’s location is considered normal. If hives or any other symptoms of anaphylaxis develop, do not continue with the treatment. 

1. For intramuscular or subcutaneous injection

Before administering, Liporase is typically combined with 1.5mL of saline solution or water for injection, using approximately 1500IU of the product. When combining the powder with saline, carefully rotate the bottle and avoid vigorous shaking. Additionally, lidocaine can be used to dissolve it, reducing the discomfort associated with injection.

1. For boosting the effectiveness of fat dissolvers

Mix 5 mL of saline with 1 vial of Liporase, and then withdraw the resulting solution. Administer the injection to the target area to enhance the efficacy of the fat-dissolving agent. It is crucial to emphasize that Liporase and fat-dissolving agents should not be combined; they must be injected or supplied one after the other to achieve optimal results.

DURATION OF EFFECT

Upon injection, Liporase initiates the dissolution of hyaluronic acid (HA). Depending on the concentration of HA, the benefits can be immediate and become fully obvious within 24-48 hours. If traces of HA remain after the initial treatment, follow-up procedures may be performed.

PACKAGING & SPECIFICATION

Packaging: 10 x 10mL vials 

Composition: 1500IU Hyaluronidase + 13.3mg Lactose hydrate

Method of Administration: Superficial dermis to the subcutaneous layer of the skin

Recommended Dosage: The dosage will be determined based on the severity of the condition, the quantity of hyaluronic acid to be eliminated or adjusted, and the specific treatment location. It is advisable to seek the guidance of a medical professional to determine the appropriate dosage for each patient.

Storage: Store Liporase in its original container at room temperature below 25°C. Keep the product away from direct sunlight.

Shelf life: 36 months from the manufacturing date

Manufacturer: Daehan New Pharm Co., Ltd., South Korea

** It is advised that Liporase be used only by medical professionals and trained aestheticians to prevent untoward adverse reactions and achieve optimal results.